منابع مشابه
INDUCTION OF TYPE 1 DIABETES IN DIABETES-RESISTA NT (BB-DR) RATS
The BioBreeding- Diabetes Prone (BB-DP) rat spontaneously develops an autoimmune diabetic syndrome that is dependent on the RT1 u Major Histocompatibility Complex (MHC) haplotype and homozygosity for an allele at the Lymphopenia (Lyp) locus. Lyp mutation is responsible for a peripheral T -lymphopenia. There are other genetic loci contributing to diabetes susceptibility in this strain. BB ra...
متن کاملMorphological Evaluation of Testis Tissue of Rats in Various Time Points after Diabetes Type 1 Induction
Abstract Objective: Previous studies have indicated the hyperglycemia-induce cell death in various tissues such as brain, kidneys, liver and especially in the testis. Recent studies have reported that diabetes can trigger male infertility. In this study we report the histological analysis of the testis tissue after diabetes type 1 induction in wistar rats. Materials and Methods: At various ti...
متن کاملinduction of type 1 diabetes in diabetes-resista nt (bb-dr) rats
the biobreeding- diabetes prone (bb-dp) rat spontaneously develops an autoimmune diabetic syndrome that is dependent on the rt1 u major histocompatibility complex (mhc) haplotype and homozygosity for an allele at the lymphopenia (lyp) locus. lyp mutation is responsible for a peripheral t -lymphopenia. there are other genetic loci contributing to diabetes susceptibility in this strain. bb rats c...
متن کاملType 1 diabetes induction in humanized mice.
There is an urgent and unmet need for humanized in vivo models of type 1 diabetes to study immunopathogenesis and immunotherapy, and in particular antigen-specific therapy. Transfer of patient blood lymphocytes to immunodeficient mice is associated with xenogeneic graft-versus-host reactivity that complicates assessment of autoimmunity. Improved models could identify which human T cells initiat...
متن کاملThe early natural history of nephropathy in type 1 diabetes: II. Early renal structural changes in type 1 diabetes.
Renal structural abnormalities are known to precede the development of proteinuria, hypertension, and reduced renal function in patients with type 1 diabetes. The determinants of these early structural abnormalities are, however, largely unknown. The International Diabetic Nephropathy Study (IDNS) has recruited 243 children and adults (aged 10-40 years) in Montreal, Minneapolis, and Paris to id...
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ژورنال
عنوان ژورنال: Clinical & Experimental Immunology
سال: 2001
ISSN: 0009-9104
DOI: 10.1046/j.1365-2249.2001.01724.x